Traits

Traits linked to CFB

complement factor B

The Human Phenotype Ontology links 17 traits to CFB, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the immune system

Trait	How often it is seen
Decreased circulating complement factor B concentration	Not recorded
Increased susceptibility to neisseria meningitidis infections	Not recorded
Meningitis	Not recorded
Pneumonia	Not recorded
Recurrent bacterial infections	Not recorded

Laboratory abnormality

Trait	How often it is seen
Blood in urine	Not recorded
Elevated creatinine	Not recorded
High urine protein levels	Not recorded
Increased blood urea nitrogen	Not recorded

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Low number of red blood cells or hemoglobin	Not recorded
Low platelet count	Not recorded
Microangiopathic hemolytic anemia	Not recorded

Abnormality of the genitourinary system

Trait	How often it is seen
Hemolytic-uremic syndrome	Often (30–79%)
Absent urine output	Not recorded
Acute kidney injury	Not recorded

Abnormality of the cardiovascular system

Trait	How often it is seen
High blood pressure	Often (30–79%)

Abnormality of the digestive system

Trait	How often it is seen
Peritonitis	Not recorded

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to CFB and how often each is seen. Find out more at hpo.jax.org.

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