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Gene

AXIN1

axin 1

Summary

Cytogenetic location
16p13.3
Coordinates
Chromosome 16: 287,440–352,723 (GRCh38)
Exons
11 exons across 65.3 kb
Protein
862 amino acids
Also known as
PPP1R49
MANE Select transcript
ENST00000262320.8NM_003502.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads AXIN1 yet. The test sequences your whole genome, so your data includes it all the same.

How AXIN1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 16, with a bracket where AXIN1 sits. AXIN1 and 45 genes near it on chromosome 16, from 1 to 820,081.Chromosome 1616p13.3p13.3p13.2p13.13p13.12p13.11p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q13q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.30.1 Mb0.2 Mb0.3 Mb0.4 Mb0.5 Mb0.6 Mb0.7 Mb0.8 MbPOLR3K: 44,356–53,663, reverse strandPOLR3KSNRNP25: 53,817–60,009, forward strandSNRNP25RHBDF1: 58,058–78,176, reverse strandRHBDF1MPG: 77,007–136,889, forward strandMPGNPRL3: 79,387–138,720, reverse strandNPRL3HBZ: 142,728–154,503, forward strandHBM: 153,892–166,770, forward strandHBMHBA2: 172,021–173,910, forward strandHBA2HBA1: 176,660–177,527, forward strandHBA1HBQ1: 180,437–181,181, forward strandHBQ1LUC7L: 188,943–229,485, reverse strandLUC7LFAM234A: 234,521–272,183, forward strandFAM234ARGS11: 268,301–275,980, reverse strandRGS11ARHGDIG: 280,386–283,010, forward strandARHGDIGPDIA2: 283,152–287,215, forward strandPDIA2AXIN1: 287,440–352,723, reverse strandAXIN1MRPL28: 365,449–371,289, reverse strandMRPL28PGAP6: 370,779–387,113, reverse strandPGAP6NME4: 396,725–410,367, forward strandNME4DECR2: 401,834–412,492, forward strandDECR2RAB11FIP3: 425,593–523,012, forward strandRAB11FIP3CAPN15: 527,698–554,636, forward strandCAPN15PRR35: 559,688–565,532, forward strandPRR35PIGQ: 566,995–584,121, forward strandPIGQNHLRC4: 567,000–569,495, forward strandNHLRC4RAB40C: 589,007–629,348, forward strandRAB40CWFIKKN1: 629,239–634,117, forward strandWFIKKN1METTL26: 634,412–636,378, reverse strandMETTL26MCRIP2: 636,817–648,475, forward strandMCRIP2WDR90: 649,287–667,837, forward strandWDR90RHOT2: 668,081–674,174, forward strandRHBDL1: 675,605–678,275, forward strandSTUB1: 679,980–682,870, forward strandJMJD8: 681,666–684,528, reverse strandWDR24: 684,614–690,444, reverse strandWDR24FBXL16: 692,498–705,860, reverse strandFBXL16METRN: 715,093–719,796, forward strandMETRNANTKMT: 720,581–722,590, forward strandANTKMTCCDC78: 722,581–726,954, reverse strandHAGHL: 726,494–735,525, forward strandCIAO3: 729,721–741,329, reverse strandMSLN: 760,729–768,866, forward strandMSLNMSLNL: 769,428–782,054, reverse strandMSLNLRPUSD1: 784,974–788,406, reverse strandRPUSD1CHTF18: 788,046–800,737, forward strandCHTF18GNG13: 798,020–800,770, reverse strandDiagram of AXIN1: 11 exons on the reverse strand of chromosome 16Exon 9: 1 known disease-causing siteExon 11: 287,440–288,248, 809 basesExon 10: 289,440–289,607, 168 basesExon 9: 291,190–291,297, 108 basesExon 8: 293,488–293,718, 231 basesExon 7: 297,056–297,226, 171 basesExon 6: 297,722–298,251, 530 basesExon 5: 304,304–304,441, 138 basesExon 4: 309,973–310,069, 97 basesExon 3: 314,543–314,683, 141 basesExon 2: 346,148–347,106, 959 basesExon 1: 352,369–352,723, 355 bases1110864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.7 kb of the gene's 65.3 kb; 2,589 of those bases code for the protein.

How a genome test reads AXIN1

1

position in AXIN1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 65.3 kb of AXIN1, introns included, not only the 3.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). AXIN1 gene: axin 1. Retrieved 16 October 2026, from https://dantelabs.com/genes/axin1

Vancouver

Dante Labs. AXIN1 gene: axin 1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/axin1

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