Traits

Traits linked to ADRA2A

adrenoceptor alpha 2A

The Human Phenotype Ontology links 12 traits to ADRA2A, by body system: features seen in people with one of the gene's rare conditions.

Laboratory abnormality

Trait	How often it is seen
Diabetes mellitus	Always
Elevated blood creatine phosphokinase	Always
High blood sugar	Always
Increased plasma triglycerides	Always
High blood uric acid level	Often (30–79%)

Abnormality of the integument

Trait	How often it is seen
Buffalo hump	Always
Darkened and thickened skin	Often (30–79%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Inability to make and keep healthy fat tissue	Always
Gout	Often (30–79%)

Abnormality of the cardiovascular system

Trait	How often it is seen
High blood pressure	Always

Abnormality of the digestive system

Trait	How often it is seen
Enlarged liver	Often (30–79%)

Abnormality of the nervous system

Trait	How often it is seen
Obstructive sleep apnea	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to ADRA2A and how often each is seen. Find out more at hpo.jax.org.

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