{
  "url": "https://dantelabs.com/traits/palmar-hyperkeratosis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "palmar-hyperkeratosis",
    "id": "HP:0010765",
    "name": "Palmar hyperkeratosis",
    "definition": "Abnormal thickening of the skin localized to the palm of the hand.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-limbs",
        "name": "Abnormality of limbs",
        "url": "https://dantelabs.com/traits/abnormality-of-limbs"
      },
      {
        "slug": "abnormality-of-the-integument",
        "name": "Abnormality of the integument",
        "url": "https://dantelabs.com/traits/abnormality-of-the-integument"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-skin-morphology-of-the-palm",
        "name": "Abnormal skin morphology of the palm",
        "url": "https://dantelabs.com/traits/abnormal-skin-morphology-of-the-palm"
      },
      {
        "slug": "hyperkeratosis",
        "name": "Hyperkeratosis",
        "url": "https://dantelabs.com/traits/hyperkeratosis"
      }
    ],
    "narrower": [
      {
        "slug": "palmoplantar-hyperkeratosis",
        "name": "Thickening of the outer layer of the skin of the palms and soles",
        "genes": 46,
        "url": "https://dantelabs.com/traits/palmoplantar-hyperkeratosis"
      }
    ],
    "genes": [
      {
        "slug": "krt1",
        "symbol": "KRT1",
        "hgnc": "HGNC:6412",
        "name": "keratin 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt1"
      },
      {
        "slug": "krt14",
        "symbol": "KRT14",
        "hgnc": "HGNC:6416",
        "name": "keratin 14",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/krt14"
      },
      {
        "slug": "krt16",
        "symbol": "KRT16",
        "hgnc": "HGNC:6423",
        "name": "keratin 16",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/krt16"
      },
      {
        "slug": "krt17",
        "symbol": "KRT17",
        "hgnc": "HGNC:6427",
        "name": "keratin 17",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt17"
      },
      {
        "slug": "krt5",
        "symbol": "KRT5",
        "hgnc": "HGNC:6442",
        "name": "keratin 5",
        "frequency": "frequent",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/krt5"
      },
      {
        "slug": "krt6a",
        "symbol": "KRT6A",
        "hgnc": "HGNC:6443",
        "name": "keratin 6A",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/krt6a"
      },
      {
        "slug": "krt6b",
        "symbol": "KRT6B",
        "hgnc": "HGNC:6444",
        "name": "keratin 6B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/krt6b"
      },
      {
        "slug": "krt9",
        "symbol": "KRT9",
        "hgnc": "HGNC:6447",
        "name": "keratin 9",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/krt9"
      },
      {
        "slug": "wnt10a",
        "symbol": "WNT10A",
        "hgnc": "HGNC:13829",
        "name": "Wnt family member 10A",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wnt10a"
      },
      {
        "slug": "nectin4",
        "symbol": "NECTIN4",
        "hgnc": "HGNC:19688",
        "name": "nectin cell adhesion molecule 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nectin4"
      },
      {
        "slug": "smarcad1",
        "symbol": "SMARCAD1",
        "hgnc": "HGNC:18398",
        "name": "SNF2 related chromatin remodeling ATPase with DExD box 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smarcad1"
      },
      {
        "slug": "zc4h2",
        "symbol": "ZC4H2",
        "hgnc": "HGNC:24931",
        "name": "zinc finger C4H2-type containing",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zc4h2"
      }
    ]
  }
}