{
  "url": "https://dantelabs.com/traits/migraine-without-aura",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "migraine-without-aura",
    "id": "HP:0002083",
    "name": "Migraine without aura",
    "definition": "Repeated headache attacks lasting 4-72 h fulfilling at least two of the following criteria: 1) unilateral location, 2) pulsating quality, 3) moderate or severe pain intensity, and 4) aggravation by or causing avoidance of routine physical activity such as climbing stairs. Headache attacks are commonly accompanied by nausea, vomiting, photophobia, or phonophobia.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      }
    ],
    "broader": [
      {
        "slug": "migraine",
        "name": "Migraine",
        "url": "https://dantelabs.com/traits/migraine"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "lamb1",
        "symbol": "LAMB1",
        "hgnc": "HGNC:6486",
        "name": "laminin subunit beta 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lamb1"
      },
      {
        "slug": "cacna1a",
        "symbol": "CACNA1A",
        "hgnc": "HGNC:1388",
        "name": "calcium voltage-gated channel subunit alpha1 A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cacna1a"
      },
      {
        "slug": "trex1",
        "symbol": "TREX1",
        "hgnc": "HGNC:12269",
        "name": "three prime repair exonuclease 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trex1"
      },
      {
        "slug": "csnk1d",
        "symbol": "CSNK1D",
        "hgnc": "HGNC:2452",
        "name": "casein kinase 1 delta",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/csnk1d"
      },
      {
        "slug": "ednra",
        "symbol": "EDNRA",
        "hgnc": "HGNC:3179",
        "name": "endothelin receptor type A",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ednra"
      },
      {
        "slug": "esr1",
        "symbol": "ESR1",
        "hgnc": "HGNC:3467",
        "name": "estrogen receptor 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/esr1"
      },
      {
        "slug": "kcnk18",
        "symbol": "KCNK18",
        "hgnc": "HGNC:19439",
        "name": "potassium two pore domain channel subfamily K member 18",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kcnk18"
      },
      {
        "slug": "tnf",
        "symbol": "TNF",
        "hgnc": "HGNC:11892",
        "name": "tumor necrosis factor",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnf"
      }
    ]
  }
}