{
  "url": "https://dantelabs.com/traits/decreased-memory-b-cell-proportion",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "decreased-memory-b-cell-proportion",
    "id": "HP:0030374",
    "name": "Decreased memory B cell proportion",
    "definition": "A reduction in the normal proportion of memory B cells (CD19+/CD27+) in circulation relative to the total number of B cells. Memory B cells develop from naive B cells. Upon antigen rechallenge, memory B cells rapidly expand and differentiate into plasma cells under the cognate control of memory Th cells (Phase IV).",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-memory-b-cell-proportion",
        "name": "Abnormal memory B cell proportion",
        "url": "https://dantelabs.com/traits/abnormal-memory-b-cell-proportion"
      }
    ],
    "narrower": [
      {
        "slug": "decreased-class-switched-memory-b-cell-proportion",
        "name": "Decreased class-switched memory B cell proportion",
        "genes": 23,
        "url": "https://dantelabs.com/traits/decreased-class-switched-memory-b-cell-proportion"
      },
      {
        "slug": "decreased-unswitched-memory-b-cell-proportion",
        "name": "Decreased unswitched memory B cell proportion",
        "genes": 2,
        "url": "https://dantelabs.com/traits/decreased-unswitched-memory-b-cell-proportion"
      }
    ],
    "genes": [
      {
        "slug": "arhgef1",
        "symbol": "ARHGEF1",
        "hgnc": "HGNC:681",
        "name": "Rho guanine nucleotide exchange factor 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arhgef1"
      },
      {
        "slug": "bach2",
        "symbol": "BACH2",
        "hgnc": "HGNC:14078",
        "name": "BACH transcriptional regulator 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bach2"
      },
      {
        "slug": "ctps1",
        "symbol": "CTPS1",
        "hgnc": "HGNC:2519",
        "name": "CTP synthase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctps1"
      },
      {
        "slug": "elf4",
        "symbol": "ELF4",
        "hgnc": "HGNC:3319",
        "name": "E74 like ETS transcription factor 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/elf4"
      },
      {
        "slug": "ikbkb",
        "symbol": "IKBKB",
        "hgnc": "HGNC:5960",
        "name": "inhibitor of nuclear factor kappa B kinase subunit beta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ikbkb"
      },
      {
        "slug": "irf4",
        "symbol": "IRF4",
        "hgnc": "HGNC:6119",
        "name": "interferon regulatory factor 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irf4"
      },
      {
        "slug": "pomp",
        "symbol": "POMP",
        "hgnc": "HGNC:20330",
        "name": "proteasome maturation protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pomp"
      },
      {
        "slug": "prkcd",
        "symbol": "PRKCD",
        "hgnc": "HGNC:9399",
        "name": "protein kinase C delta",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkcd"
      },
      {
        "slug": "kdm6a",
        "symbol": "KDM6A",
        "hgnc": "HGNC:12637",
        "name": "lysine demethylase 6A",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm6a"
      },
      {
        "slug": "kmt2d",
        "symbol": "KMT2D",
        "hgnc": "HGNC:7133",
        "name": "lysine methyltransferase 2D",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kmt2d"
      },
      {
        "slug": "il27ra",
        "symbol": "IL27RA",
        "hgnc": "HGNC:17290",
        "name": "interleukin 27 receptor subunit alpha",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il27ra"
      },
      {
        "slug": "sp110",
        "symbol": "SP110",
        "hgnc": "HGNC:5401",
        "name": "SP110 nuclear body protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sp110"
      },
      {
        "slug": "tom1",
        "symbol": "TOM1",
        "hgnc": "HGNC:11982",
        "name": "target of myb1 membrane trafficking protein",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tom1"
      }
    ]
  }
}