{
  "url": "https://dantelabs.com/traits/abnormal-circulating-immunoglobulin-concentration",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "abnormal-circulating-immunoglobulin-concentration",
    "id": "HP:0010701",
    "name": "Abnormal circulating immunoglobulin concentration",
    "definition": "An abnormal deviation from normal levels of immunoglobulins in blood.",
    "synonyms": [
      "Abnormal immunoglobulin concentration",
      "Abnormal immunoglobulin level",
      "Abnormal serum immunoglobulin concentration",
      "Abnormal serum immunoglobulin levels",
      "Abnormal serum level of immunoglobulin",
      "Immunoglobulin abnormality"
    ],
    "systems": [
      {
        "slug": "abnormal-cellular-phenotype",
        "name": "Abnormal cellular phenotype",
        "url": "https://dantelabs.com/traits/abnormal-cellular-phenotype"
      },
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      },
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-b-cell-physiology",
        "name": "Abnormality of B cell physiology",
        "url": "https://dantelabs.com/traits/abnormal-b-cell-physiology"
      },
      {
        "slug": "abnormality-of-humoral-immunity",
        "name": "Abnormality of humoral immunity",
        "url": "https://dantelabs.com/traits/abnormality-of-humoral-immunity"
      }
    ],
    "narrower": [
      {
        "slug": "decreased-circulating-immunoglobulin-concentration",
        "name": "Decreased circulating antibody level",
        "genes": 96,
        "url": "https://dantelabs.com/traits/decreased-circulating-immunoglobulin-concentration"
      },
      {
        "slug": "increased-circulating-immunoglobulin-concentration",
        "name": "Increased antibody level in blood",
        "genes": 31,
        "url": "https://dantelabs.com/traits/increased-circulating-immunoglobulin-concentration"
      },
      {
        "slug": "abnormal-circulating-igm-concentration",
        "name": "Abnormal circulating IgM concentration",
        "genes": 3,
        "url": "https://dantelabs.com/traits/abnormal-circulating-igm-concentration"
      },
      {
        "slug": "abnormal-circulating-igg-concentration",
        "name": "Abnormal circulating IgG concentration",
        "genes": 2,
        "url": "https://dantelabs.com/traits/abnormal-circulating-igg-concentration"
      },
      {
        "slug": "abnormal-circulating-iga-concentration",
        "name": "Abnormal circulating IgA concentration",
        "genes": 1,
        "url": "https://dantelabs.com/traits/abnormal-circulating-iga-concentration"
      },
      {
        "slug": "absent-circulating-kappa-chain-bearing-immunoglobulin",
        "name": "Absent circulating kappa chain-bearing immunoglobulin",
        "genes": 1,
        "url": "https://dantelabs.com/traits/absent-circulating-kappa-chain-bearing-immunoglobulin"
      },
      {
        "slug": "abnormal-circulating-igd-concentration",
        "name": "Abnormal circulating IgD concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-igd-concentration"
      },
      {
        "slug": "abnormal-circulating-ige-concentration",
        "name": "Abnormal circulating IgE concentration",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-circulating-ige-concentration"
      }
    ],
    "genes": [
      {
        "slug": "ikbkg",
        "symbol": "IKBKG",
        "hgnc": "HGNC:5961",
        "name": "inhibitor of nuclear factor kappa B kinase regulatory subunit gamma",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ikbkg"
      },
      {
        "slug": "il2rg",
        "symbol": "IL2RG",
        "hgnc": "HGNC:6010",
        "name": "interleukin 2 receptor subunit gamma",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/il2rg"
      },
      {
        "slug": "nfkbia",
        "symbol": "NFKBIA",
        "hgnc": "HGNC:7797",
        "name": "NFKB inhibitor alpha",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nfkbia"
      },
      {
        "slug": "cd28",
        "symbol": "CD28",
        "hgnc": "HGNC:1653",
        "name": "CD28 molecule",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd28"
      },
      {
        "slug": "ctla4",
        "symbol": "CTLA4",
        "hgnc": "HGNC:2505",
        "name": "cytotoxic T-lymphocyte associated protein 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctla4"
      },
      {
        "slug": "slc7a7",
        "symbol": "SLC7A7",
        "hgnc": "HGNC:11065",
        "name": "solute carrier family 7 member 7",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc7a7"
      },
      {
        "slug": "tnfrsf1b",
        "symbol": "TNFRSF1B",
        "hgnc": "HGNC:11917",
        "name": "TNF receptor superfamily member 1B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfrsf1b"
      },
      {
        "slug": "smarcal1",
        "symbol": "SMARCAL1",
        "hgnc": "HGNC:11102",
        "name": "SNF2 related chromatin remodeling annealing helicase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smarcal1"
      }
    ]
  }
}