Variants
TP53 variants
Predicted effect: In-frame insertion or deletion. 3 of the 162 TP53 variants with a page here, most review stars first. Each page describes ClinVar's public record of the variant, never a result.
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
| Variant | HGVS c. | Exon or intron | Position (GRCh38) | ClinVar classification | Review status |
|---|---|---|---|---|---|
| A161_Y163delinsD | c.482_487del | Exon 5 | 7,675,124 | Likely pathogenic | 3 stars out of 4 reviewed by expert panel |
| G108_L111delinsIQ | c.322_332delinsATTCA | Exon 4 | 7,676,037 | Likely pathogenic | 3 stars out of 4 reviewed by expert panel |
| L252_I254del | c.754_762del | Exon 7 | 7,674,200 | Pathogenic | 3 stars out of 4 reviewed by expert panel |