Traits

Traits linked to THBD

thrombomodulin

The Human Phenotype Ontology links 15 traits to THBD, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Blood clot in a deep vein	Often (30–79%)
Hypercoagulability	Not recorded
Low number of red blood cells or hemoglobin	Not recorded
Low platelet count	Not recorded
Microangiopathic hemolytic anemia	Not recorded

Laboratory abnormality

Trait	How often it is seen
Blood in urine	Not recorded
Elevated creatinine	Not recorded
High urine protein levels	Not recorded
Increased blood urea nitrogen	Not recorded

Abnormality of the genitourinary system

Trait	How often it is seen
Hemolytic-uremic syndrome	Always
Absent urine output	Not recorded
Acute kidney injury	Not recorded

Abnormality of the cardiovascular system

Trait	How often it is seen
Blood clot in artery of lung	Often (30–79%)
High blood pressure	Often (30–79%)

Abnormality of the immune system

Trait	How often it is seen
Decreased circulating complement C3 concentration	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to THBD and how often each is seen. Find out more at hpo.jax.org.

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