Traits

Traits linked to ROS1

ROS proto-oncogene 1, receptor tyrosine kinase

The Human Phenotype Ontology links 8 traits to ROS1, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the digestive system

Trait	How often it is seen
Biliary tract neoplasm	Very often (80–99%)
Jaundice	Very often (80–99%)
Abdominal pain	Sometimes (5–29%)
Anorexia	Sometimes (5–29%)

Laboratory abnormality

Trait	How often it is seen
Clay colored stools	Very often (80–99%)
Fever	Sometimes (5–29%)

Abnormality of the integument

Trait	How often it is seen
Itching	Often (30–79%)

Constitutional symptom

Trait	How often it is seen
Fatigue	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to ROS1 and how often each is seen. Find out more at hpo.jax.org.

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