Traits

Traits linked to RIGI

RNA sensor RIG-I

The Human Phenotype Ontology links 9 traits to RIGI, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the cardiovascular system

Trait	How often it is seen
Aortic valve calcification	Often (30–79%)
Narrowing of aortic valve	Sometimes (5–29%)

Abnormality of the integument

Trait	How often it is seen
Hyperkeratosis	Always
Psoriasiform lesion	Often (30–79%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Joint subluxation	Sometimes (5–29%)
Osteopenia	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Breakdown of small bones of fingers	Always

Abnormality of the eye

Trait	How often it is seen
Glaucoma	Very often (80–99%)

Growth abnormality

Trait	How often it is seen
Short stature	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to RIGI and how often each is seen. Find out more at hpo.jax.org.

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