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Gene

NAPB

NSF attachment protein beta

Summary

Cytogenetic location
20p11.21
Coordinates
Chromosome 20: 23,374,522–23,421,488 (GRCh38)
Exons
11 exons across 47 kb
Protein
298 amino acids
Also known as
SNAP-BETA, SNAPB
MANE Select transcript
ENST00000377026.4NM_022080.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Epilepsy (Full Panel)

      • Epilepsy

        One of 171 genes linked to it

        A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.

        • 3 GenCC submitters rate it definitive or strong

    How NAPB is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 20, with a bracket where NAPB sits. NAPB and 15 genes near it on chromosome 20, from 22,898,005 to 23,898,004.Chromosome 2020p11.21p13p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12q13.11q13.12q13.13q13.2q13.31q13.32q13.3323 Mb23.2 Mb23.4 Mb23.6 Mb23.8 MbSSTR4: 23,035,312–23,039,237, forward strandSSTR4THBD: 23,045,633–23,049,672, reverse strandTHBDCD93: 23,065,139–23,086,393, reverse strandCD93NXT1: 23,350,148–23,354,771, forward strandNXT1GZF1: 23,361,987–23,373,084, forward strandGZF1NAPB: 23,374,522–23,421,488, reverse strandNAPBCSTL1: 23,426,104–23,444,930, forward strandCSTL1CST11: 23,450,403–23,453,210, reverse strandCST11CST8: 23,491,101–23,496,010, forward strandCST8CST9L: 23,564,731–23,568,517, reverse strandCST9LCST9: 23,602,410–23,605,917, reverse strandCST9CST3: 23,626,706–23,638,556, reverse strandCST3CST4: 23,685,640–23,689,038, reverse strandCST4CST1: 23,747,560–23,751,268, reverse strandCST1CST2: 23,823,769–23,826,735, reverse strandCST2CST5: 23,875,934–23,880,086, reverse strandCST5Diagram of NAPB: 11 exons on the reverse strand of chromosome 20Exon 4: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 11: 23,374,522–23,377,486, 2,965 basesExon 10: 23,379,445–23,379,495, 51 basesExon 9: 23,379,867–23,379,935, 69 basesExon 8: 23,381,213–23,381,317, 105 basesExon 7: 23,389,946–23,390,030, 85 basesExon 6: 23,390,209–23,390,264, 56 basesExon 5: 23,394,922–23,394,999, 78 basesExon 4: 23,395,139–23,395,185, 47 basesExon 3: 23,397,072–23,397,188, 117 basesExon 2: 23,402,993–23,403,072, 80 basesExon 1: 23,421,305–23,421,488, 184 bases1110864215′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 3.8 kb of the gene's 47 kb; 897 of those bases code for the protein.

    How a genome test reads NAPB

    2

    positions in NAPB where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 47 kb of NAPB, introns included, not only the 3.8 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). NAPB gene: NSF attachment protein beta. Retrieved 17 October 2026, from https://dantelabs.com/genes/napb

    Vancouver

    Dante Labs. NAPB gene: NSF attachment protein beta [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/napb

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