Traits

Traits linked to G6PD

glucose-6-phosphate dehydrogenase

The Human Phenotype Ontology links 16 traits to G6PD, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Fava bean-induced hemolytic anemia	Always
Elevated white blood count	Not recorded
Heinz bodies	Not recorded
Increased immature red blood cells	Not recorded
Nonspherocytic hemolytic anemia	Not recorded
Poikilocytosis	Not recorded
Unequal size of red blood cells	Not recorded

Laboratory abnormality

Trait	How often it is seen
Decreased circulating glucose-6-phosphate dehydrogenase activity	Always
Fever	Always
Hemoglobin in urine	Not recorded
Unconjugated hyperbilirubinemia	Not recorded

Abnormality of the digestive system

Trait	How often it is seen
Abdominal pain	Always
Jaundice	Always
Prolonged yellowing of skin in newborn	Always

Abnormality of the cardiovascular system

Trait	How often it is seen
Increased spleen size	Very often (80–99%)

Abnormality of the integument

Trait	How often it is seen
Paleness	Not recorded

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to G6PD and how often each is seen. Find out more at hpo.jax.org.

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