Traits

Traits linked to DLG4

discs large MAGUK scaffold protein 4

The Human Phenotype Ontology links 12 traits to DLG4, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Intellectual disability	Always
Autism spectrum disorder	Often (30–79%)
Cerebellar vermis atrophy	Often (30–79%)
Epilepsy	Often (30–79%)

Abnormality of limbs

Trait	How often it is seen
Dropped arches	Often (30–79%)
Increased arm span	Often (30–79%)
Long slender fingers	Not recorded

Abnormality of the musculoskeletal system

Trait	How often it is seen
Scoliosis	Always
Double-Jointed	Often (30–79%)

Abnormality of the eye

Trait	How often it is seen
Cross-eyed	Often (30–79%)

Abnormality of the integument

Trait	How often it is seen
Stretch marks	Often (30–79%)

Growth abnormality

Trait	How often it is seen
Disproportionate tall stature	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to DLG4 and how often each is seen. Find out more at hpo.jax.org.

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