Traits

Traits linked to CD274

CD274 molecule

The Human Phenotype Ontology links 11 traits to CD274, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Delayed speech and language development	Often (30–79%)
Epilepsy	Often (30–79%)
Intellectual disability, mild	Often (30–79%)
Interictal EEG abnormality	Often (30–79%)

Abnormality of the immune system

Trait	How often it is seen
Anti-thyroid peroxidase antibody positivity	Always
Asthma	Often (30–79%)
Unusual bronchiolitis	Often (30–79%)

Abnormality of the endocrine system

Trait	How often it is seen
Reduced circulating growth hormone concentration	Often (30–79%)
Underactive thyroid	Often (30–79%)

Laboratory abnormality

Trait	How often it is seen
Decreased circulating C-peptide concentration	Always
Type 1 diabetes	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to CD274 and how often each is seen. Find out more at hpo.jax.org.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test