{
  "url": "https://dantelabs.com/traits/spermatogenesis-maturation-arrest",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "spermatogenesis-maturation-arrest",
    "id": "HP:0031038",
    "name": "Spermatogenesis maturation arrest",
    "definition": "Maturation arrest (MA) is defined as germ cells that fail to complete maturation. Uniform MA is characterized by spermatogenic arrest at the same stage of spermatogenesis throughout the seminiferous tubules. MA is subcategorized into early MA, in which only spermatogonia or spermatocytes are found, and late MA, in which spermatids are detected without spermatozoa.",
    "synonyms": [
      "Meiotic maturation arrest of spermatogenesis"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-spermatogenesis",
        "name": "Abnormal sperm development",
        "url": "https://dantelabs.com/traits/abnormal-spermatogenesis"
      }
    ],
    "narrower": [
      {
        "slug": "spermatocyte-maturation-arrest",
        "name": "Spermatocyte maturation arrest",
        "genes": 6,
        "url": "https://dantelabs.com/traits/spermatocyte-maturation-arrest"
      },
      {
        "slug": "round-spermatid-arrest",
        "name": "Round spermatid arrest",
        "genes": 1,
        "url": "https://dantelabs.com/traits/round-spermatid-arrest"
      }
    ],
    "genes": [
      {
        "slug": "mov10l1",
        "symbol": "MOV10L1",
        "hgnc": "HGNC:7201",
        "name": "Mov10 like RNA helicase 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mov10l1"
      },
      {
        "slug": "msh5",
        "symbol": "MSH5",
        "hgnc": "HGNC:7328",
        "name": "mutS homolog 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/msh5"
      },
      {
        "slug": "pnldc1",
        "symbol": "PNLDC1",
        "hgnc": "HGNC:21185",
        "name": "PARN like ribonuclease domain containing exonuclease 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pnldc1"
      },
      {
        "slug": "rbbp7",
        "symbol": "RBBP7",
        "hgnc": "HGNC:9890",
        "name": "RB binding protein 7, chromatin remodeling factor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rbbp7"
      },
      {
        "slug": "syce1",
        "symbol": "SYCE1",
        "hgnc": "HGNC:28852",
        "name": "synaptonemal complex central element protein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/syce1"
      },
      {
        "slug": "tdrd9",
        "symbol": "TDRD9",
        "hgnc": "HGNC:20122",
        "name": "tudor domain containing 9",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tdrd9"
      },
      {
        "slug": "terb1",
        "symbol": "TERB1",
        "hgnc": "HGNC:26675",
        "name": "telomere repeat binding bouquet formation protein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/terb1"
      },
      {
        "slug": "terb2",
        "symbol": "TERB2",
        "hgnc": "HGNC:28520",
        "name": "telomere repeat binding bouquet formation protein 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/terb2"
      },
      {
        "slug": "tex11",
        "symbol": "TEX11",
        "hgnc": "HGNC:11733",
        "name": "testis expressed 11",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tex11"
      },
      {
        "slug": "xrcc2",
        "symbol": "XRCC2",
        "hgnc": "HGNC:12829",
        "name": "X-ray repair cross complementing 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/xrcc2"
      },
      {
        "slug": "m1ap",
        "symbol": "M1AP",
        "hgnc": "HGNC:25183",
        "name": "meiosis 1 associated protein",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/m1ap"
      }
    ]
  }
}