Skip to content
Use your HSA or FSA funds

Trait

Intervertebral disk degeneration

The presence of degenerative changes of intervertebral disk.

HPO HP:0008419

Summary

Also called
Degeneration of intervertebral discs, Degeneration of intervertebral disks, Degenerative disc disease, Degenerative disk disease, Degenerative intervertebral disc, Degenerative intervertebral disk
Body system
Abnormality of the musculoskeletal system

7 genes linked to Intervertebral disk degeneration

Changes in these genes cause rare conditions in which Intervertebral disk degeneration is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
MIR140microRNA 140AlwaysIn 1 condition
LMNAlamin A/COften (30–79%)In 1 condition
SMAD2SMAD family member 2Often (30–79%)In 1 condition
SMAD3SMAD family member 3Often (30–79%)In 2 conditions
MATN3matrilin 3Sometimes (5–29%)In 1 condition
TBX1T-box transcription factor 1Sometimes (5–29%)In 1 condition
HGDhomogentisate 1,2-dioxygenaseNot recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal intervertebral disk morphology

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test