{
  "url": "https://dantelabs.com/traits/intervertebral-disk-degeneration",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "intervertebral-disk-degeneration",
    "id": "HP:0008419",
    "name": "Intervertebral disk degeneration",
    "definition": "The presence of degenerative changes of intervertebral disk.",
    "synonyms": [
      "Degeneration of intervertebral discs",
      "Degeneration of intervertebral disks",
      "Degenerative disc disease",
      "Degenerative disk disease",
      "Degenerative intervertebral disc",
      "Degenerative intervertebral disk"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-intervertebral-disk-morphology",
        "name": "Abnormal intervertebral disk morphology",
        "url": "https://dantelabs.com/traits/abnormal-intervertebral-disk-morphology"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "mir140",
        "symbol": "MIR140",
        "hgnc": "HGNC:31527",
        "name": "microRNA 140",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mir140"
      },
      {
        "slug": "lmna",
        "symbol": "LMNA",
        "hgnc": "HGNC:6636",
        "name": "lamin A/C",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmna"
      },
      {
        "slug": "smad2",
        "symbol": "SMAD2",
        "hgnc": "HGNC:6768",
        "name": "SMAD family member 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/smad2"
      },
      {
        "slug": "smad3",
        "symbol": "SMAD3",
        "hgnc": "HGNC:6769",
        "name": "SMAD family member 3",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/smad3"
      },
      {
        "slug": "matn3",
        "symbol": "MATN3",
        "hgnc": "HGNC:6909",
        "name": "matrilin 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/matn3"
      },
      {
        "slug": "tbx1",
        "symbol": "TBX1",
        "hgnc": "HGNC:11592",
        "name": "T-box transcription factor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx1"
      },
      {
        "slug": "hgd",
        "symbol": "HGD",
        "hgnc": "HGNC:4892",
        "name": "homogentisate 1,2-dioxygenase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hgd"
      }
    ]
  }
}