{
  "url": "https://dantelabs.com/traits/giant-cell-hepatitis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "giant-cell-hepatitis",
    "id": "HP:0200084",
    "name": "Giant cell hepatitis",
    "definition": "Chronic hepatitis characterized by parenchymal inflammation with formation of large multinucleated hepatocytes in response to a variety of insults to the liver.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-digestive-system",
        "name": "Abnormality of the digestive system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-digestive-system"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "hepatitis",
        "name": "Liver inflammation",
        "url": "https://dantelabs.com/traits/hepatitis"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "amacr",
        "symbol": "AMACR",
        "hgnc": "HGNC:451",
        "name": "alpha-methylacyl-CoA racemase",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/amacr"
      },
      {
        "slug": "akr1d1",
        "symbol": "AKR1D1",
        "hgnc": "HGNC:388",
        "name": "aldo-keto reductase family 1 member D1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/akr1d1"
      },
      {
        "slug": "vps33b",
        "symbol": "VPS33B",
        "hgnc": "HGNC:12712",
        "name": "VPS33B late endosome and lysosome associated",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vps33b"
      },
      {
        "slug": "hsd3b7",
        "symbol": "HSD3B7",
        "hgnc": "HGNC:18324",
        "name": "hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hsd3b7"
      },
      {
        "slug": "vipas39",
        "symbol": "VIPAS39",
        "hgnc": "HGNC:20347",
        "name": "VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vipas39"
      }
    ]
  }
}