Traits

Traits linked to WASHC4

WASH complex subunit 4

The Human Phenotype Ontology links 19 traits to WASHC4, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Delayed ability to walk	Always
Delayed fine motor development	Always
Delayed speech and language development	Always
Global developmental delay	Always
Intellectual disability	Always
IQ less than 20	Always
Profound global developmental delay	Always
Self-injurious behavior	Often (30–79%)

Abnormality of head or neck

Trait	How often it is seen
Broad nasal tip	Always
Abnormally small head	Often (30–79%)
Highly arched eyebrow	Often (30–79%)
Prominent forehead	Often (30–79%)
Thin red part of the upper lip	Often (30–79%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Low muscle tone	Always
Involuntary muscle stiffness, contraction, or spasm	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Low-set ears	Often (30–79%)

Abnormality of the eye

Trait	How often it is seen
Cross-eyed	Often (30–79%)

Abnormality of the integument

Trait	How often it is seen
Dorsal hirsutism	Often (30–79%)

Growth abnormality

Trait	How often it is seen
Short stature	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to WASHC4 and how often each is seen. Find out more at hpo.jax.org.

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