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Gene

TRUB2

TruB pseudouridine synthase family member 2

Summary

Cytogenetic location
9q34.11
Coordinates
Chromosome 9: 128,305,159–128,322,447 (GRCh38)
Exons
8 exons across 17.3 kb
Protein
331 amino acids
Also known as
CLONE24922
MANE Select transcript
ENST00000372890.6NM_015679.3
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

No Genome Test report reads TRUB2 yet. The test sequences your whole genome, so your data includes it all the same.

How TRUB2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 9, with a bracket where TRUB2 sits. TRUB2 and 31 genes near it on chromosome 9, from 127,813,803 to 128,813,802.Chromosome 99q34.11p24.3p24.2p24.1p23p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q13q21.11q21.12q21.13q21.2q21.31q21.32q21.33q22.1q22.2q22.31q22.32q22.33q31.1q31.2q31.3q32q33.1q33.2q33.3q34.11q34.12q34.13q34.2q34.3128 Mb128.2 Mb128.4 Mb128.6 Mb128.8 MbFPGS: 127,794,597–127,815,065, forward strandFPGSENG: 127,811,130–127,855,232, reverse strandENGAK1: 127,866,435–127,878,558, reverse strandAK1: 127,867,850–127,906,022, reverse strandST6GALNAC6: 127,885,320–127,906,632, reverse strandST6GALNAC4: 127,906,919–127,917,057, reverse strandST6GALNAC4PIP5KL1: 127,920,881–127,930,823, reverse strandPIP5KL1DPM2: 127,935,090–127,937,879, reverse strandDPM2EEIG1: 127,939,491–127,981,075, reverse strandEEIG1NAIF1: 128,061,233–128,068,206, reverse strandNAIF1SLC25A25: 128,068,169–128,109,245, forward strandSLC25A25PTGES2: 128,120,693–128,128,462, reverse strandPTGES2LCN2: 128,149,071–128,153,454, forward strandLCN2BBLN: 128,160,219–128,163,928, forward strandBBLNCIZ1: 128,161,233–128,204,482, reverse strandCIZ1DNM1: 128,191,655–128,255,254, forward strandDNM1GOLGA2: 128,255,829–128,276,036, reverse strandGOLGA2SWI5: 128,275,379–128,316,123, forward strandSWI5TRUB2: 128,305,159–128,322,447, reverse strandTRUB2COQ4: 128,322,483–128,334,073, forward strandCOQ4SLC27A4: 128,340,475–128,363,283, forward strandSLC27A4URM1: 128,371,341–128,392,017, forward strandURM1CERCAM: 128,411,575–128,437,362, forward strandCERCAMODF2: 128,455,181–128,502,162, forward strandODF2GLE1: 128,504,655–128,543,874, forward strandGLE1SPTAN1: 128,552,558–128,633,663, forward strandSPTAN1DYNC2I2: 128,633,646–128,656,847, reverse strandDYNC2I2SET: 128,683,424–128,696,400, forward strandSETPKN3: 128,702,489–128,720,924, forward strandPKN3ZDHHC12: 128,720,862–128,724,146, reverse strandZDHHC12ZER1: 128,729,785–128,772,414, reverse strandZER1TBC1D13: 128,787,227–128,810,432, forward strandTBC1D13Diagram of TRUB2: 8 exons on the reverse strand of chromosome 9Exon 8: 128,305,159–128,309,875, 4,717 basesExon 7: 128,310,887–128,311,023, 137 basesExon 6: 128,311,529–128,311,601, 73 basesExon 5: 128,313,808–128,313,889, 82 basesExon 4: 128,315,567–128,315,628, 62 basesExon 3: 128,317,152–128,317,226, 75 basesExon 2: 128,321,599–128,321,730, 132 basesExon 1: 128,322,300–128,322,447, 148 bases876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.4 kb of the gene's 17.3 kb; 996 of those bases code for the protein.

Sequencing TRUB2

2Easy

How hard TRUB2 is to sequence with short reads, out of 100

Almost all of TRUB2's exons sit where short reads map cleanly.

What adds to it: the share of TRUB2's exons in each kind of hard region

  • Mappability1.1%
  • Homology0%
  • Repeats5.9%
  • GC content4.1%
  • Reference coverage0%

A Dante Labs score from our own research, built on NIST's Genome in a Bottle maps of hard-to-sequence regions.How it's scored

1

position in TRUB2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 17.3 kb of TRUB2, introns included, not only the 5.4 kb of exons.

ClinVar pathogenic variants (1)

The TRUB2 variants ClinVar classifies pathogenic or likely pathogenic for any condition, reviewed by at least one submitter with criteria, and the most reviewed of them. It is ClinVar's public record of the gene, never a result.

  • Likely pathogenic 1
VariantConditionsClinVar classificationReview status
NM_016035.5(COQ4):c.202+4A>C (opens in a new tab)neonatal encephalomyopathy-cardiomyopathy-respiratory distress syndromeLikely pathogenic2 stars out of 4 criteria provided, multiple submitters, no conflicts

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Genome in a Bottle genome stratifications, from NIST: the sequencing difficulty score.
  • Data release 2026.10.18-8b139e39.

Cite this page

APA

Dante Labs. (n.d.). TRUB2 gene: TruB pseudouridine synthase family member 2. Retrieved 18 October 2026, from https://dantelabs.com/genes/trub2

Vancouver

Dante Labs. TRUB2 gene: TruB pseudouridine synthase family member 2 [Internet]. [cited 18 October 2026]. Available from: https://dantelabs.com/genes/trub2

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