Traits

Traits linked to MYC

MYC proto-oncogene, bHLH transcription factor

The Human Phenotype Ontology links 16 traits to MYC, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the digestive system

Trait	How often it is seen
Abdominal pain	Sometimes (5–29%)
Abnormality of the liver	Sometimes (5–29%)
Abnormality of the pancreas	Sometimes (5–29%)
Intestinal obstruction	Sometimes (5–29%)
Nausea and vomiting	Sometimes (5–29%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Bone marrow disease	Often (30–79%)
Decreased total CD4+ T cell proportion	Sometimes (5–29%)
Gastrointestinal bleeding	Sometimes (5–29%)
Burkitt lymphoma	Not recorded

Abnormality of the cardiovascular system

Trait	How often it is seen
Abnormal lymph node histology	Sometimes (5–29%)
Abnormality of the spleen	Sometimes (5–29%)

Laboratory abnormality

Trait	How often it is seen
High blood uric acid level	Often (30–79%)
Increased circulating lactate dehydrogenase concentration	Often (30–79%)

Abnormality of head or neck

Trait	How often it is seen
Mouth tumor	Often (30–79%)

Abnormality of the genitourinary system

Trait	How often it is seen
Abnormality of the ovary	Sometimes (5–29%)

Abnormality of the immune system

Trait	How often it is seen
Decreased immune function	Not recorded

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to MYC and how often each is seen. Find out more at hpo.jax.org.

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