Traits

Traits linked to MLPH

melanophilin

The Human Phenotype Ontology links 6 traits to MLPH, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the integument

Trait	How often it is seen
Large clumps of pigment irregularly distributed along hair shaft	Always
Silver-gray hair	Always
Loss of hair color	Very often (80–99%)
Partial absent skin pigmentation	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
White eyelashes	Always

Abnormality of the eye

Trait	How often it is seen
Light eye color	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to MLPH and how often each is seen. Find out more at hpo.jax.org.

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