Traits

Traits linked to KRT18

keratin 18

The Human Phenotype Ontology links 14 traits to KRT18, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the digestive system

Trait	How often it is seen
Accumulation of fluid in the abdomen	Always
Enlarged vein in esophagus	Always
Scar tissue replaces healthy tissue in the liver	Often (30–79%)
Biliary cirrhosis	Sometimes (5–29%)
Fulminant hepatitis	Sometimes (5–29%)
Abdominal bloating	Not recorded
Jaundice	Not recorded
Micronodular cirrhosis	Not recorded

Laboratory abnormality

Trait	How often it is seen
Fever	Not recorded
Increased level of L-fucose in urine	Not recorded
Increased level of propylene glycol in blood	Not recorded

Abnormality of the cardiovascular system

Trait	How often it is seen
High blood pressure	Not recorded
Increased blood pressure in blood vessels of lungs	Not recorded

Abnormality of the nervous system

Trait	How often it is seen
Lethargy	Not recorded

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to KRT18 and how often each is seen. Find out more at hpo.jax.org.

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