Traits

Traits linked to IRAK4

interleukin 1 receptor associated kinase 4

The Human Phenotype Ontology links 14 traits to IRAK4, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the immune system

Trait	How often it is seen
Complete or near-complete absence of specific antibody response to unconjugated pneumococcus polysaccharide	Always
Meningitis	Always
Recurrent staphylococcal infections	Always
Recurrent streptococcal infections	Always
Decreased immune function	Very often (80–99%)
Recurrent bacterial infections	Very often (80–99%)
Recurrent streptococcus pneumoniae infections	Very often (80–99%)
Recurrent bacterial skin infections	Often (30–79%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Low blood neutrophil count	Very often (80–99%)
Transiently decreased total neutrophil count	Not recorded

Abnormal cellular phenotype

Trait	How often it is seen
Increased circulating IgE concentration	Often (30–79%)

Abnormality of the digestive system

Trait	How often it is seen
Liver abscess	Often (30–79%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Infected joint	Always

Laboratory abnormality

Trait	How often it is seen
Fever	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to IRAK4 and how often each is seen. Find out more at hpo.jax.org.

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