Traits

Traits linked to GZF1

GDNF inducible zinc finger protein 1

The Human Phenotype Ontology links 15 traits to GZF1, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the eye

Trait	How often it is seen
Severe near sightedness	Always
Birth defect that causes a hole in the innermost layer at the back of the eye	Often (30–79%)
Cat eye	Often (30–79%)
Retinal detachment	Often (30–79%)
Glaucoma	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Double-Jointed	Always
Multiple joint dislocation	Often (30–79%)
Pigeon chest	Often (30–79%)
Kyphoscoliosis	Sometimes (5–29%)
Rounded neck	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Inguinal hernia	Sometimes (5–29%)
Umbilical hernia	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Club feet	Often (30–79%)

Abnormality of the ear

Trait	How often it is seen
Hearing impairment	Often (30–79%)

Growth abnormality

Trait	How often it is seen
Short stature	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to GZF1 and how often each is seen. Find out more at hpo.jax.org.

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