Traits

Traits linked to DLG3

discs large MAGUK scaffold protein 3

The Human Phenotype Ontology links 14 traits to DLG3, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Delayed speech and language development	Always
Intellectual disability	Always
Motor delay	Always
Attention deficit	Often (30–79%)
Epilepsy	Sometimes (5–29%)
Global developmental delay	Not recorded

Abnormality of head or neck

Trait	How often it is seen
High palate	Often (30–79%)
Upward slanting of the opening between the eyelids	Often (30–79%)
Zygomatic flattening	Often (30–79%)
Bifid uvula	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Low muscle tone	Often (30–79%)
Narrow chest	Often (30–79%)

Abnormality of the eye

Trait	How often it is seen
Cross-eyed	Often (30–79%)

Abnormality of the genitourinary system

Trait	How often it is seen
Enuresis	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to DLG3 and how often each is seen. Find out more at hpo.jax.org.

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