Traits

Traits linked to CD70

CD70 molecule

The Human Phenotype Ontology links 10 traits to CD70, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Reduced total natural killer cell count	Always
Hodgkin lymphoma	Very often (80–99%)
Lymphoproliferative disorder	Not recorded

Abnormality of the immune system

Trait	How often it is seen
Partial absence of specific antibody response to tetanus vaccine	Often (30–79%)
Recurrent infections	Often (30–79%)
Severe varicella zoster infection	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Enlarged liver and spleen	Always
Swollen lymph nodes	Always

Abnormal cellular phenotype

Trait	How often it is seen
Decreased circulating antibody level	Often (30–79%)

Laboratory abnormality

Trait	How often it is seen
Episodic fever	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to CD70 and how often each is seen. Find out more at hpo.jax.org.

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