Traits

Traits linked to ADAM9

ADAM metallopeptidase domain 9

The Human Phenotype Ontology links 16 traits to ADAM9, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the eye

Trait	How often it is seen
Abnormal retinal pigmentation	Very often (80–99%)
Difficulties with night vision	Very often (80–99%)
Extreme sensitivity of the eyes to light	Very often (80–99%)
Abnormal color vision	Often (30–79%)
Abnormal full-field electroretinogram	Often (30–79%)
Blind spot located at fixation point	Often (30–79%)
Color blindness	Often (30–79%)
Optic disc pallor	Often (30–79%)
Progressive loss of vision	Often (30–79%)
Retinal atrophy	Often (30–79%)
Spicular pigmentation of the retina	Often (30–79%)
Involuntary, rapid, rhythmic eye movements	Sometimes (5–29%)
Metamorphopsia	Sometimes (5–29%)
Visual impairment	Sometimes (5–29%)
Cone/cone-rod dystrophy	Not recorded

Abnormality of the cardiovascular system

Trait	How often it is seen
Narrowing of blood vessels in back of eye	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to ADAM9 and how often each is seen. Find out more at hpo.jax.org.

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