Trait

Ventricular preexcitation

An abnormality in which the cardiac ventricles depolarize too early as a result of an abnormality of cardiac conduction pathways such as an accessory pathway.

HPO HP:0004309

Also called: Pre-excitation syndrome, Preexcitation, Ventricular pre-excitation
Body system: Abnormality of the cardiovascular system

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13 genes linked to Ventricular preexcitation

Changes in these genes cause rare conditions in which Ventricular preexcitation is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
PRKAG2protein kinase AMP-activated non-catalytic subunit gamma 2	Always	In 2 conditions
DNAJC30DnaJ heat shock protein family (Hsp40) member C30	Sometimes (5–29%)	In 1 condition
MT-ATP6mitochondrially encoded ATP synthase membrane subunit 6	Sometimes (5–29%)	In 1 condition
MT-CO1mitochondrially encoded cytochrome c oxidase I	Sometimes (5–29%)	In 1 condition
MT-CO3mitochondrially encoded cytochrome c oxidase III	Sometimes (5–29%)	In 1 condition
MT-CYBmitochondrially encoded cytochrome b	Sometimes (5–29%)	In 1 condition
MT-ND1mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1	Sometimes (5–29%)	In 1 condition
MT-ND2mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2	Sometimes (5–29%)	In 1 condition
MT-ND4mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4	Sometimes (5–29%)	In 1 condition
MT-ND4Lmitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4L	Sometimes (5–29%)	In 1 condition
MT-ND5mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5	Sometimes (5–29%)	In 1 condition
MT-ND6mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6	Sometimes (5–29%)	In 1 condition
NDUFS2NADH:ubiquinone oxidoreductase core subunit S2	Sometimes (5–29%)	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Ventricular arrhythmia

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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