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Trait

Symmetric T2-signal increase with T1-signal decrease in the putamen

A symmetric magnetic resonance imaing (MRI) abnormality of the basal ganglia characterized by an increase of signal intensity in T2-weighted images and a corresponding signal decrease on T1-weighted images.

HPO HP:0007039

Summary

Body system
Abnormality of the nervous system

1 gene linked to Symmetric T2-signal increase with T1-signal decrease in the putamen

Changes in these genes cause rare conditions in which Symmetric T2-signal increase with T1-signal decrease in the putamen is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
PDE8Bphosphodiesterase 8BAlwaysIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal basal ganglia morphology

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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