Trait

Prominent U wave

Increased amplitude of the U wave, defined as an amplitude greater than 1-2mm or 25 percent of the height of the T wave.

HPO HP:0025072

Also called: Increased U wave amplitude
Body system: Abnormality of the cardiovascular system

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4 genes linked to Prominent U wave

Changes in these genes cause rare conditions in which Prominent U wave is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
KCNJ2potassium inwardly rectifying channel subfamily J member 2	Sometimes (5–29%)	In 2 conditions
KCNJ5potassium inwardly rectifying channel subfamily J member 5	Sometimes (5–29%)	In 1 condition
CLCNKBchloride voltage-gated channel Kb	Rarely (1–4%)	In 1 condition
SLC12A3solute carrier family 12 member 3	Rarely (1–4%)	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal U wave

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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