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Trait

Increased CSF interferon alpha

Increased concentration of interferon alpha in the cerebrospinal fluid (CSF).

HPO HP:0009709

Summary

Body system
Laboratory abnormalityAbnormality of the nervous system

9 genes linked to Increased CSF interferon alpha

Changes in these genes cause rare conditions in which Increased CSF interferon alpha is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
ADARadenosine deaminase RNA specificAlwaysIn 2 conditions
TREX1three prime repair exonuclease 1AlwaysIn 2 conditions
IFIH1interferon induced with helicase C domain 1Often (30–79%)In 1 condition
LSM11LSM11, U7 small nuclear RNA associatedOften (30–79%)In 1 condition
RNASEH2Aribonuclease H2 subunit AOften (30–79%)In 1 condition
RNASEH2Bribonuclease H2 subunit BOften (30–79%)In 1 condition
RNASEH2Cribonuclease H2 subunit COften (30–79%)In 1 condition
RNU7-1RNA, U7 small nuclear 1Often (30–79%)In 1 condition
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1Often (30–79%)In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal CSF metabolite concentration

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

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