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Trait

Gonadotropin deficiency

A reduced ability to secrete gonadotropins, which are protein hormones secreted by gonadotrope cells of the anterior pituitary gland, including the hormones follitropin (FSH) and luteinizing hormone (LH).

HPO HP:0008213

Summary

Also called
Pituitary gonadotropin deficiency
Body system
Abnormality of the endocrine systemAbnormality of the nervous system

9 genes linked to Gonadotropin deficiency

Changes in these genes cause rare conditions in which Gonadotropin deficiency is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
FSHBfollicle stimulating hormone subunit betaAlwaysIn 1 condition
OTX2orthodenticle homeobox 2AlwaysIn 1 condition
LHX3LIM homeobox 3Very often (80–99%)In 2 conditions
GLI3GLI family zinc finger 3Often (30–79%)In 1 condition
NKX2-1NK2 homeobox 1Often (30–79%)In 1 condition
PCSK1proprotein convertase subtilisin/kexin type 1Sometimes (5–29%)In 1 condition
POMCproopiomelanocortinSometimes (5–29%)In 2 conditions
CHD7chromodomain helicase DNA binding protein 7Not recordedIn 1 condition
FGFR1fibroblast growth factor receptor 1Not recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Anterior hypopituitarism

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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