Traits

Traits linked to ZFR

zinc finger RNA binding protein

The Human Phenotype Ontology links 13 traits to ZFR, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Abnormal myelination	Often (30–79%)
Abnormality of movement	Often (30–79%)
Babinski sign	Often (30–79%)
Global developmental delay	Often (30–79%)
Hand tremor	Often (30–79%)
Increased reflexes	Often (30–79%)
Intellectual disability, mild	Often (30–79%)
Peripheral neuropathy	Often (30–79%)
Underdevelopment of part of brain called corpus callosum	Often (30–79%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Lower limb spasticity	Often (30–79%)
Progressive spastic paraplegia	Often (30–79%)
Spastic walk	Often (30–79%)
EMG abnormality	Not recorded

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to ZFR and how often each is seen. Find out more at hpo.jax.org.

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