Traits

Traits linked to WFDC2

WAP four-disulfide core domain 2

The Human Phenotype Ontology links 8 traits to WFDC2, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the respiratory system

Trait	How often it is seen
Cough	Always
Decreased nasal nitric oxide	Always
Neonatal respiratory distress	Always
Reduced forced expiratory volume in one second	Always
Permanent enlargement of the airways of the lungs	Very often (80–99%)

Abnormality of head or neck

Trait	How often it is seen
Chronic sinus disease	Always
Nasal polyposis	Always

Abnormality of the ear

Trait	How often it is seen
Recurrent middle ear infection	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to WFDC2 and how often each is seen. Find out more at hpo.jax.org.

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