Variant
TP53 S362Afs*8
NM_000546.6(TP53):c.1083del (p.Ser362AlafsTer8)
- p.Ser362AlafsTer8
- p.S362Afs*8
- rs1555524354
- ClinVar classification
- Pathogenic
- Review status
- 2 stars out of 4criteria provided, multiple submitters, no conflicts
- Last evaluated
- 25 January 2023
Data current to ClinVar release 2026-10-12 · Dante Labs data release 2026.10.16-c6eea6bfFacts last changed 16 October 2026
This page as data
Add .json to the page's address, or ask for application/json, to read it as JSON.
library(jsonlite)
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page$variant$nameSummary
S362Afs*8 is a frameshift variant in TP53: it adds or removes DNA letters in a way that shifts how the rest of the gene's code is read. ClinVar classifies it as pathogenic for bone marrow failure syndrome 5 (criteria provided, multiple submitters, no conflicts).
ClinVar classifications
| Condition | Classification | Review status | Submissions | Last evaluated |
|---|---|---|---|---|
| bone marrow failure syndrome 5ClinVar VCV000549856 (opens in a new tab) | Pathogenic | 2 stars out of 4criteria provided, multiple submitters, no conflicts | 2 submissions | 25 January 2023 |
Classifications as ClinVar records them in release 2026-10-12. ClinVar updates them as evidence is reviewed.
Where it lies in TP53
S362Afs*8 lies in exon 10 of the 11 in TP53's MANE Select transcript, NM_000546.6.
Molecular details
| Gene | TP53 |
|---|---|
| Transcript | NM_000546.6MANE Select |
| Coding DNA change (HGVS c.) | c.1083del |
| Protein change (HGVS p.) | p.Ser362AlafsTer8p.S362Afs*8 |
| Predicted consequence | Frameshiftframeshift_variant (opens in a new tab)frameshift_truncation (opens in a new tab) |
| Predicted impact | High |
| Position (GRCh38) | chr17:7670625 TC>T |
| Position (GRCh37) | chr17:7573943 TC>T |
| dbSNP ID | rs1555524354 (opens in a new tab) |
| ClinVar Variation ID | VCV000549856 (opens in a new tab) |
| ClinVar Allele ID | 540581 |
| ClinGen Allele Registry ID | CA645587291 (opens in a new tab) |
| ClinVar name | NM_000546.6(TP53):c.1083del (p.Ser362fs) |
TP53 S362Afs*8 in other databases
Reports that look at this variant (1)
These Genome Test condition reports include S362Afs*8 among the variants they look at.
| Report | Conditions | Inheritance |
|---|---|---|
| Rare Inherited Bone Marrow Failure Syndromes | Bone Marrow Failure Syndrome |
Other variants in TP53
- A138PLikely pathogenic3 stars out of 4
- A138VLikely pathogenic3 stars out of 4
- A161_Y163delinsDLikely pathogenic3 stars out of 4
- A347DPathogenic3 stars out of 4
- c.-29+1G>TLikely pathogenic3 stars out of 4
- c.97-1G>APathogenic3 stars out of 4
- c.375+5G>ALikely pathogenic3 stars out of 4
- c.919+1G>APathogenic3 stars out of 4
- c.993+1delLikely pathogenic3 stars out of 4
- C124XPathogenic3 stars out of 4
Limitations
This page describes publicly available information about a genetic variant. It is not a diagnosis, and it says nothing about whether you or anyone else carries this variant.
Classifications come from ClinVar and change as new evidence is reviewed. A classification here may differ from the one in ClinVar today, or from the one a laboratory reports.
Whole genome sequencing with short reads can miss or miscall some variants, particularly in repeated or highly similar stretches of DNA and in large insertions, deletions or rearrangements.
If you have questions about a variant in your own results or in your family, talk to a genetic counsellor or your doctor.
Sources & credits
- Classifications from ClinVar (release 2026-10-12), National Center for Biotechnology Information.
- Condition terms from the Mondo Disease Ontology (release 2026-10-06), used under CC BY 4.0.
- Gene symbols and names from the HUGO Gene Nomenclature Committee (release 2026-10-16).
- Allele identifiers from the ClinGen Allele Registry (release 2026-10-16-c4908f54).
- Reference SNP identifiers from dbSNP (release b157), National Center for Biotechnology Information.
- Gene–disease links from the Gene Curation Coalition, GenCC (release 2026-10-16).
- Difficult regions from the Genome in a Bottle Consortium (release v3.6).
- Transcripts from MANE (release v1.5), NCBI and EMBL-EBI.
- Predicted consequences from mehari (release 0.11.0), with transcript models from cdot.
- Built from Dante Labs data release 2026.10.16-c6eea6bf of 16 October 2026.
Cite this page
Dante Labs. (16 October 2026). TP53 S362Afs*8 (c.1083del, rs1555524354) (Version 2026.10.16-c6eea6bf). Retrieved 17 October 2026, from https://dantelabs.com/genes/tp53/variants/s362afs8
Dante Labs. TP53 S362Afs*8 (c.1083del, rs1555524354) [Internet]. Version 2026.10.16-c6eea6bf. 16 October 2026 [cited 17 October 2026]. Available from: https://dantelabs.com/genes/tp53/variants/s362afs8
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