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Gene

TOPBP1

DNA topoisomerase II binding protein 1

Summary

Cytogenetic location
3q22.1
Coordinates
Chromosome 3: 133,600,238–133,661,941 (GRCh38)
Exons
28 exons across 61.7 kb
Protein
1,522 amino acids
Also known as
KIAA0259, TOP2BP1, Dpb11
MANE Select transcript
ENST00000260810.10NM_007027.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads TOPBP1 yet. The test sequences your whole genome, so your data includes it all the same.

How TOPBP1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 3, with a bracket where TOPBP1 sits. TOPBP1 and 8 genes near it on chromosome 3, from 133,131,090 to 134,131,089.Chromosome 33q22.1p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q29133.2 Mb133.4 Mb133.6 Mb133.8 Mb134 MbTMEM108: 133,038,276–133,397,775, forward strandTMEM108BFSP2: 133,400,056–133,475,222, forward strandBFSP2CDV3: 133,573,543–133,590,274, forward strandCDV3TOPBP1: 133,600,238–133,661,941, reverse strandTOPBP1TF: 133,745,862–133,796,641, forward strandTFSRPRB: 133,784,023–133,825,772, forward strandSRPRBRAB6B: 133,819,939–133,895,889, reverse strandRAB6BSLCO2A1: 133,930,258–134,052,184, reverse strandSLCO2A1RYK: 134,065,303–134,250,929, reverse strandRYKDiagram of TOPBP1: 28 exons on the reverse strand of chromosome 3Exon 28: 133,600,238–133,601,393, 1,156 basesExon 27: 133,608,535–133,608,696, 162 basesExon 26: 133,608,873–133,608,962, 90 basesExon 25: 133,611,004–133,611,141, 138 basesExon 24: 133,612,389–133,612,552, 164 basesExon 23: 133,616,814–133,616,925, 112 basesExon 22: 133,617,160–133,617,326, 167 basesExon 21: 133,618,213–133,618,433, 221 basesExon 20: 133,620,155–133,620,347, 193 basesExon 19: 133,623,091–133,623,193, 103 basesExon 18: 133,623,311–133,623,457, 147 basesExon 17: 133,624,052–133,624,175, 124 basesExon 16: 133,628,362–133,628,471, 110 basesExon 15: 133,628,560–133,628,733, 174 basesExon 14: 133,637,876–133,638,162, 287 basesExon 13: 133,639,959–133,640,170, 212 basesExon 12: 133,643,200–133,643,372, 173 basesExon 11: 133,644,020–133,644,363, 344 basesExon 10: 133,649,383–133,649,633, 251 basesExon 9: 133,649,780–133,649,943, 164 basesExon 8: 133,652,463–133,652,629, 167 basesExon 7: 133,653,345–133,653,524, 180 basesExon 6: 133,655,290–133,655,486, 197 basesExon 5: 133,656,676–133,656,857, 182 basesExon 4: 133,657,798–133,657,941, 144 basesExon 3: 133,659,016–133,659,150, 135 basesExon 2: 133,661,044–133,661,134, 91 basesExon 1: 133,661,769–133,661,941, 173 bases2825201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.8 kb of the gene's 61.7 kb; 4,569 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.

Cite this page

APA

Dante Labs. (n.d.). TOPBP1 gene: DNA topoisomerase II binding protein 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/topbp1

Vancouver

Dante Labs. TOPBP1 gene: DNA topoisomerase II binding protein 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/topbp1

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