Traits

Traits linked to SPRY2

sprouty RTK signaling antagonist 2

The Human Phenotype Ontology links 6 traits to SPRY2, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the genitourinary system

Trait	How often it is seen
Stage 5 chronic kidney disease	Sometimes (5–29%)
IgA deposition in the glomerulus	Not recorded
Mesangial hypercellularity	Not recorded

Laboratory abnormality

Trait	How often it is seen
Blood in urine	Often (30–79%)
High urine protein levels	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
High blood pressure	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to SPRY2 and how often each is seen. Find out more at hpo.jax.org.

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