Traits

Traits linked to SERPINC1

serpin family C member 1

The Human Phenotype Ontology links 15 traits to SERPINC1, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Decreased level of heparin co-factor II	Always
Recurrent thrombophlebitis	Always
Reduced antithrombin antigen	Very often (80–99%)
Reduced antithrombin III activity	Very often (80–99%)
Blood clot in a deep vein	Often (30–79%)
Recurrent thromboembolism	Often (30–79%)
Superficial thrombophlebitis	Often (30–79%)
Blood clot in artery	Sometimes (5–29%)
Blood clot in liver vein	Sometimes (5–29%)
Blood clot in portal vein	Sometimes (5–29%)
Mesenteric venous thrombosis	Sometimes (5–29%)
Blood clot in cerebral vein	Rarely (1–4%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Blood clot in artery of lung	Often (30–79%)
Retinal venous occlusion	Sometimes (5–29%)
Arterial occlusion	Not recorded

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to SERPINC1 and how often each is seen. Find out more at hpo.jax.org.

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