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Gene

PGLS

6-phosphogluconolactonase

Summary

Cytogenetic location
19p13.11
Coordinates
Chromosome 19: 17,511,649–17,521,288 (GRCh38)
Exons
5 exons across 9.6 kb
Protein
258 amino acids
Also known as
6PGL
MANE Select transcript
ENST00000252603.7NM_012088.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads PGLS yet. The test sequences your whole genome, so your data includes it all the same.

How PGLS is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 19, with a bracket where PGLS sits. PGLS and 37 genes near it on chromosome 19, from 17,016,469 to 18,016,468.Chromosome 1919p13.11p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.4317.2 Mb17.4 Mb17.6 Mb17.8 Mb18 MbCPAMD8: 16,892,951–17,026,982, reverse strandCPAMD8HAUS8: 17,049,729–17,075,625, reverse strandHAUS8MYO9B: 17,075,728–17,214,537, forward strandMYO9BUSE1: 17,215,337–17,220,245, forward strandUSE1OCEL1: 17,226,198–17,229,219, forward strandOCEL1NR2F6: 17,229,207–17,245,953, reverse strandNR2F6: 17,235,940–17,255,448, reverse strandUSHBP1: 17,249,171–17,282,786, reverse strandBABAM1: 17,267,343–17,281,249, forward strand: 17,267,418–17,282,966, forward strandANKLE1: 17,281,645–17,287,649, forward strandABHD8: 17,292,131–17,310,236, reverse strandABHD8MRPL34: 17,292,543–17,306,847, forward strandDDA1: 17,309,518–17,323,315, forward strandDDA1ANO8: 17,323,223–17,334,864, reverse strandANO8GTPBP3: 17,334,920–17,342,735, forward strandGTPBP3PLVAP: 17,351,450–17,377,356, reverse strandPLVAPCCDC194: 17,387,196–17,394,201, reverse strandCCDC194BST2: 17,402,933–17,407,393, reverse strandBST2MVB12A: 17,405,722–17,436,364, forward strandMVB12ATMEM221: 17,435,509–17,448,679, reverse strandTMEM221: 17,436,611–17,460,804, reverse strandNXNL1: 17,455,425–17,460,926, reverse strandNXNL1SLC27A1: 17,467,666–17,506,190, forward strandSLC27A1PGLS: 17,511,649–17,521,288, forward strandPGLSNIBAN3: 17,523,301–17,553,839, forward strandNIBAN3COLGALT1: 17,555,590–17,583,162, forward strandCOLGALT1UNC13A: 17,601,327–17,688,382, reverse strandUNC13AMAP1S: 17,719,242–17,734,515, forward strandMAP1SFCHO1: 17,747,701–17,788,572, forward strandFCHO1B3GNT3: 17,794,697–17,814,175, forward strandB3GNT3INSL3: 17,816,512–17,821,574, reverse strandINSL3JAK3: 17,824,780–17,848,071, reverse strandJAK3RPL18A: 17,859,868–17,871,283, forward strandRPL18ASLC5A5: 17,871,939–17,895,174, forward strandSLC5A5CCDC124: 17,932,588–17,944,914, forward strandCCDC124KCNN1: 17,947,484–18,000,085, forward strandKCNN1ARRDC2: 18,001,126–18,015,694, forward strandARRDC2Diagram of PGLS: 5 exons on the forward strand of chromosome 19Exon 1: 17,511,649–17,511,960, 312 basesExon 2: 17,516,173–17,516,280, 108 basesExon 3: 17,517,288–17,517,389, 102 basesExon 4: 17,517,710–17,517,850, 141 basesExon 5: 17,520,944–17,521,288, 345 bases123455′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1 kb of the gene's 9.6 kb; 777 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.

Cite this page

APA

Dante Labs. (n.d.). PGLS gene: 6-phosphogluconolactonase. Retrieved 17 October 2026, from https://dantelabs.com/genes/pgls

Vancouver

Dante Labs. PGLS gene: 6-phosphogluconolactonase [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/pgls

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