Traits

Traits linked to FBXW4

F-box and WD repeat domain containing 4

The Human Phenotype Ontology links 8 traits to FBXW4, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of limbs

Trait	How often it is seen
Oligodactyly	Very often (80–99%)
Finger syndactyly	Often (30–79%)
Hand monodactyly	Often (30–79%)
Split foot	Often (30–79%)
Absent hand	Sometimes (5–29%)
Split hand	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Sensorineural hearing impairment	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Absent iris	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to FBXW4 and how often each is seen. Find out more at hpo.jax.org.

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