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Gene

DEFA3

defensin alpha 3

Summary

Cytogenetic location
8p23.1
Coordinates
Chromosome 8: 7,015,869–7,018,297 (GRCh38)
Exons
3 exons across 2.4 kb
Protein
94 amino acids
Also known as
HNP-3
Previous symbols
DEF3
MANE Select transcript
ENST00000327857.7NM_005217.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads DEFA3 yet. The test sequences your whole genome, so your data includes it all the same.

How DEFA3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 8, with a bracket where DEFA3 sits. DEFA3 and 27 genes near it on chromosome 8, from 6,517,083 to 7,517,082.Chromosome 88p23.1p23.3p23.2p23.1p22p21.3p21.2p21.1p12p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.3q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.36.6 Mb6.8 Mb7 Mb7.2 Mb7.4 MbMCPH1: 6,406,592–6,648,508, forward strandMCPH1ANGPT2: 6,499,632–6,563,436, reverse strandANGPT2AGPAT5: 6,708,334–6,761,604, forward strandAGPAT5XKR5: 6,805,013–6,835,536, reverse strandXKR5DEFB1: 6,870,592–6,877,943, reverse strandDEFB1DEFA6: 6,924,697–6,926,076, reverse strandDEFA6DEFA4: 6,935,820–6,938,313, reverse strandDEFA4DEFA1: 6,977,649–6,980,094, reverse strandDEFA1DEFA1B: 6,996,766–6,999,206, reverse strandDEFA1BDEFA3: 7,015,869–7,018,297, reverse strandDEFA3DEFA5: 7,055,251–7,056,740, reverse strandDEFA5FAM90A15: 7,256,904–7,259,914, forward strandFAM90A15FAM90A3: 7,264,526–7,267,536, forward strandFAM90A3FAM90A13: 7,279,770–7,282,780, forward strandFAM90A13FAM90A5: 7,287,392–7,290,402, forward strandFAM90A5FAM90A20: 7,295,014–7,298,024, forward strandDEFB109B: 7,312,722–7,320,096, forward strandUSP17L1: 7,332,387–7,333,979, forward strandUSP17L4: 7,337,115–7,338,707, forward strandUSP17L4ZNF705G: 7,355,517–7,385,558, reverse strandZNF705GDEFB108C: 7,373,114–7,377,500, forward strandDEFB108CDEFB4B: 7,414,855–7,416,863, reverse strandDEFB4BDEFB103B: 7,428,888–7,430,348, reverse strandDEFB103BSPAG11B: 7,442,684–7,463,674, reverse strandSPAG11BDEFB104B: 7,470,308–7,475,082, reverse strandDEFB104BDEFB106B: 7,482,504–7,486,400, reverse strandDEFB105B: 7,487,679–7,489,593, forward strandDEFB107B: 7,495,911–7,509,311, forward strandDiagram of DEFA3: 3 exons on the reverse strand of chromosome 8Exon 3: 7,015,869–7,016,099, 231 basesExon 2: 7,016,676–7,016,862, 187 basesExon 1: 7,018,222–7,018,297, 76 bases3215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 0.5 kb of the gene's 2.4 kb; 285 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.

Cite this page

APA

Dante Labs. (n.d.). DEFA3 gene: defensin alpha 3. Retrieved 17 October 2026, from https://dantelabs.com/genes/defa3

Vancouver

Dante Labs. DEFA3 gene: defensin alpha 3 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/defa3

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