Traits

Traits linked to CFHR5

complement factor H related 5

The Human Phenotype Ontology links 9 traits to CFHR5, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the genitourinary system

Trait	How often it is seen
Glomerular C3 deposition	Always
Glomerular subendothelial electron-dense deposits	Always
Mesangial hypercellularity	Very often (80–99%)
Mesangial matrix expansion	Very often (80–99%)
Thickening of glomerular capillary wall	Very often (80–99%)
Renal failure	Often (30–79%)
Glomerulonephritis	Not recorded
Stage 5 chronic kidney disease	Not recorded

Laboratory abnormality

Trait	How often it is seen
Small amount of blood in urine	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to CFHR5 and how often each is seen. Find out more at hpo.jax.org.

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