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Gene

ALOX5

arachidonate 5-lipoxygenase

Summary

Cytogenetic location
10q11.21
Coordinates
Chromosome 10: 45,374,216–45,446,117 (GRCh38)
Exons
14 exons across 71.9 kb
Protein
674 amino acids
Also known as
5-LOX
MANE Select transcript
ENST00000374391.7NM_000698.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads ALOX5 yet. The test sequences your whole genome, so your data includes it all the same.

How ALOX5 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 10, with a bracket where ALOX5 sits. ALOX5 and 9 genes near it on chromosome 10, from 44,910,167 to 45,910,166.Chromosome 1010q11.21p15.3p15.2p15.1p14p13p12.33p12.32p12.31p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.31q23.32q23.33q24.1q24.2q24.31q24.32q24.33q25.1q25.2q25.3q26.11q26.12q26.13q26.2q26.345 Mb45.2 Mb45.4 Mb45.6 Mb45.8 MbTMEM72: 44,911,215–44,937,010, forward strandTMEM72RASSF4: 44,959,407–44,996,006, forward strandRASSF4DEPP1: 44,970,981–44,978,816, reverse strandDEPP1ZNF22: 45,000,262–45,007,206, forward strandZNF22OR13A1: 45,302,295–45,315,608, reverse strandOR13A1ALOX5: 45,374,216–45,446,117, forward strandALOX5MARCHF8: 45,454,585–45,594,931, reverse strandMARCHF8ZFAND4: 45,613,374–45,673,047, reverse strandZFAND4WASHC2C: 45,727,193–45,792,967, forward strandWASHC2CAGAP4: 45,825,594–45,853,875, reverse strandAGAP4Diagram of ALOX5: 14 exons on the forward strand of chromosome 10Exon 1: 45,374,216–45,374,429, 214 basesExon 2: 45,382,483–45,382,681, 199 basesExon 3: 45,395,855–45,395,936, 82 basesExon 4: 45,412,191–45,412,313, 123 basesExon 5: 45,424,041–45,424,147, 107 basesExon 6: 45,424,960–45,425,132, 173 basesExon 7: 45,428,618–45,428,764, 147 basesExon 8: 45,440,430–45,440,633, 204 basesExon 9: 45,441,344–45,441,430, 87 basesExon 10: 45,443,038–45,443,216, 179 basesExon 11: 45,443,416–45,443,537, 122 basesExon 12: 45,443,728–45,443,828, 101 basesExon 13: 45,444,116–45,444,286, 171 basesExon 14: 45,445,508–45,446,117, 610 bases1510145′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.5 kb of the gene's 71.9 kb; 2,025 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.

Cite this page

APA

Dante Labs. (n.d.). ALOX5 gene: arachidonate 5-lipoxygenase. Retrieved 17 October 2026, from https://dantelabs.com/genes/alox5

Vancouver

Dante Labs. ALOX5 gene: arachidonate 5-lipoxygenase [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/alox5

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