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Risk score · Longevity & ageing

Macular Degeneration Polygenic Risk Score

Age-related macular degeneration affects the centre of the retina and is a leading cause of sight loss in older adults. Genetics plays a large part.

A risk score adds up many common variants, each with a small effect, into an estimate of genetic predisposition. It is not a diagnosis.

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A polygenic score for Age-related macular degeneration

Genetic variants

47

Method

Independent variants associated with AMD

Built from studies of

European 100%

Evaluated in

Multi-ancestry 100%

Published

Zekavat SM et al. (2022). Photoreceptor Layer Thinning Is an Early Biomarker for Age-Related Macular Degeneration: Epidemiologic and Genetic Evidence from UK Biobank OCT Data. Ophthalmology.

The score in the PGS Catalog →

References

  1. Fritsche LG, Igl W, Bailey JN, Grassmann F, Sengupta S, Bragg-Gresham JL, 2016. A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. Nat Genet

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One kit, sent to your home. Your entire genome sequenced at the clinical standard used for diagnostic decisions. Physician-ready reports delivered to your Genome Manager in 6–8 weeks — permanent and updated as science advances.

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