Trait

Undetectable light-adapted electroretinogram

No detectable response to the light-adapted 3.0 ERG (single-flash cone response). This type of ERG measures responses of the cone system; a-waves arise from cone photoreceptors and cone off-bipolar cells; the b-wave comes from On- and Off-cone bipolar cells.

HPO HP:0030465

Also called: Absent photopic (cone) responses on ERG, non-detectable photopic ERG
Body system: Abnormality of the eye

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8 genes linked to Undetectable light-adapted electroretinogram

Changes in these genes cause rare conditions in which Undetectable light-adapted electroretinogram is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
CFAP20cilia and flagella associated protein 20	Always	In 1 condition
CNGA3cyclic nucleotide gated channel subunit alpha 3	Always	In 2 conditions
ATF6activating transcription factor 6	Very often (80–99%)	In 1 condition
CNGB3cyclic nucleotide gated channel subunit beta 3	Very often (80–99%)	In 1 condition
GNAT2G protein subunit alpha transducin 2	Very often (80–99%)	In 1 condition
PDE6Cphosphodiesterase 6C	Very often (80–99%)	In 2 conditions
PDE6Hphosphodiesterase 6H	Very often (80–99%)	In 1 condition
RPGRretinitis pigmentosa GTPase regulator	Very often (80–99%)	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal light-adapted electroretinogram

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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