Trait

Trichorrhexis invaginata

A type of hair shaft dysmorphology in which the proximal part of the hair shaft overlaps the distal part, showing a bamboo-like appearance. This feature is pathognomic for Netherton syndrome, and can be ascertained by light microscopy.

HPO HP:0025811

Also called: Bamboo hair, Helical hair
Body system: Abnormality of the integument

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1 gene linked to Trichorrhexis invaginata

Changes in these genes cause rare conditions in which Trichorrhexis invaginata is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
SPINK5serine peptidase inhibitor Kazal type 5	Very often (80–99%)	In 2 conditions

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal hairshaft morphology

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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