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Trait

Small intestinal dysmotility

Abnormal small intestinal contractions, such as spasms and intestinal paralysis related to the loss of the ability of the gut to coordinate muscular activity because of endogenous or exogenous causes.

HPO HP:0012850

Summary

Body system
Abnormality of the digestive system

6 genes linked to Small intestinal dysmotility

Changes in these genes cause rare conditions in which Small intestinal dysmotility is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
MYO1Hmyosin IHAlwaysIn 1 condition
LIG3DNA ligase 3Very often (80–99%)In 1 condition
POLGDNA polymerase gamma, catalytic subunitVery often (80–99%)In 1 condition
RRM2Bribonucleotide reductase regulatory TP53 inducible subunit M2BVery often (80–99%)In 1 condition
TYMPthymidine phosphorylaseVery often (80–99%)In 1 condition
CPOXcoproporphyrinogen oxidaseSometimes (5–29%)In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Gastrointestinal dysmotility

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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