Trait

Wasting of pec muscles

Clinical name: Pectoralis amyotrophy

Wasting of the pectoral muscles, i.e., of the pectoralis major and pectoralis minor. This finding is often manifested by prominent axillary creases or double axillary creases.

HPO HP:0012037

Body system: Abnormality of the musculoskeletal system

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6 genes linked to Wasting of pec muscles

Changes in these genes cause rare conditions in which Wasting of pec muscles is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
CAPN3calpain 3	Often (30–79%)	In 1 condition
DNMT3BDNA methyltransferase 3 beta	Often (30–79%)	In 1 condition
DUX4double homeobox 4	Often (30–79%)	In 1 condition
DUX4L1double homeobox 4 like 1 (pseudogene)	Often (30–79%)	In 1 condition
FRG1FSHD region gene 1	Often (30–79%)	In 1 condition
SMCHD1structural maintenance of chromosomes flexible hinge domain containing 1	Often (30–79%)	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal pec muscles Muscle degeneration

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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